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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1846 1
1884 1
1935 1
1936 1
1939 2
1943 1
1945 1
1949 1
1953 2
1954 3
1960 3
1961 1
1963 1
1964 2
1967 2
1968 2
1970 1
1971 3
1973 4
1975 17
1976 15
1977 12
1978 10
1979 16
1980 22
1981 14
1982 16
1983 20
1984 21
1985 23
1986 26
1987 30
1988 25
1989 45
1990 38
1991 32
1992 65
1993 64
1994 79
1995 86
1996 87
1997 122
1998 157
1999 175
2000 188
2001 210
2002 255
2003 329
2004 403
2005 469
2006 523
2007 596
2008 666
2009 773
2010 946
2011 1059
2012 1193
2013 1320
2014 1507
2015 1768
2016 1958
2017 2119
2018 2193
2019 2600
2020 2912
2021 3267
2022 3222
2023 3265
2024 1272

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32,290 results

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Page 1
The value of applied science.
[No authors listed] [No authors listed] Nat Commun. 2023 Feb 3;14(1):587. doi: 10.1038/s41467-023-36307-4. Nat Commun. 2023. PMID: 36737609 Free PMC article.
Every area of science can contribute to the changes that are required for a sustainable future through the application of its fundamental discoveries. While some fields have clear paths to application, Nature Communications believes that there is great potential for utilit …
Every area of science can contribute to the changes that are required for a sustainable future through the application of its fundamental …
Why replication has more scientific value than original discovery.
Ioannidis JPA. Ioannidis JPA. Behav Brain Sci. 2018 Jan;41:e137. doi: 10.1017/S0140525X18000729. Behav Brain Sci. 2018. PMID: 31064545
The presumed dominance of "original discovery" over replication is an anomaly. Original discovery has more value than replication primarily when scientific investigation can immediately generate numerous discoveries most of which are true and accurate. …
The presumed dominance of "original discovery" over replication is an anomaly. Original discovery has more value than r …
Significance-Based Essential Protein Discovery.
Liu Y, Liang H, Zou Q, He Z. Liu Y, et al. IEEE/ACM Trans Comput Biol Bioinform. 2022 Jan-Feb;19(1):633-642. doi: 10.1109/TCBB.2020.3004364. Epub 2022 Feb 3. IEEE/ACM Trans Comput Biol Bioinform. 2022. PMID: 32750873
After calculating the p-value for each protein, the false discovery rate is used as the error rate in the multiple testing correction procedure. Our significance-based essential protein discovery method is named as SigEP, which is tested on both simulated net …
After calculating the p-value for each protein, the false discovery rate is used as the error rate in the multiple testing cor …
Single-Cell Metabolomics.
Emara S, Amer S, Ali A, Abouleila Y, Oga A, Masujima T. Emara S, et al. Adv Exp Med Biol. 2017;965:323-343. doi: 10.1007/978-3-319-47656-8_13. Adv Exp Med Biol. 2017. PMID: 28132186 Review.
Certainly, advanced technologies such as nanodevices and microfluidic arrays are making great progress, and analytical techniques, such as matrix-assisted laser desorption ionization (MALDI), are gaining popularity with high-throughput methodology. Nevertheless, live single-cell …
Certainly, advanced technologies such as nanodevices and microfluidic arrays are making great progress, and analytical techniques, such as m …
The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery.
Guo D, Heitman LH, IJzerman AP. Guo D, et al. ACS Med Chem Lett. 2016 Aug 19;7(9):819-21. doi: 10.1021/acsmedchemlett.6b00273. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660682 Free PMC article.
In the past decade drug research community has started to appreciate the indispensable role of ligand-receptor binding kinetics (BK) in drug discovery. Next to the classical equilibrium-based drug evaluation process with affinity and potency values as outcomes, kine …
In the past decade drug research community has started to appreciate the indispensable role of ligand-receptor binding kinetics (BK) in drug …
The roles, challenges, and merits of the p value.
Chén OY, Bodelet JS, Saraiva RG, Phan H, Di J, Nagels G, Schwantje T, Cao H, Gou J, Reinen JM, Xiong B, Zhi B, Wang X, de Vos M. Chén OY, et al. Patterns (N Y). 2023 Dec 8;4(12):100878. doi: 10.1016/j.patter.2023.100878. eCollection 2023 Dec 8. Patterns (N Y). 2023. PMID: 38106615 Free PMC article. Review.
Since the 18th century, the p value has been an important part of hypothesis-based scientific investigation. As statistical and data science engines accelerate, questions emerge: to what extent are scientific discoveries based on p values reliable and reprodu …
Since the 18th century, the p value has been an important part of hypothesis-based scientific investigation. As statistical and data …
Drug discovery in prostate cancer mouse models.
Valkenburg KC, Pienta KJ. Valkenburg KC, et al. Expert Opin Drug Discov. 2015;10(9):1011-24. doi: 10.1517/17460441.2015.1052790. Epub 2015 Jun 1. Expert Opin Drug Discov. 2015. PMID: 26027638 Free PMC article. Review.
AREAS COVERED: The authors discuss the similarities and differences between mice and men; the types of mouse models that exist to model prostate cancer; practical questions one must ask when using a mouse as a model; and potential reasons that drugs do not often translate to huma …
AREAS COVERED: The authors discuss the similarities and differences between mice and men; the types of mouse models that exist to model pros …
Competition-based control of the false discovery proportion.
Luo D, Ebadi A, Emery K, He Y, Noble WS, Keich U. Luo D, et al. Biometrics. 2023 Dec;79(4):3472-3484. doi: 10.1111/biom.13830. Epub 2023 Jan 30. Biometrics. 2023. PMID: 36652258
Recently, Barber and Candes laid the theoretical foundation for a general framework for false discovery rate (FDR) control based on the notion of "knockoffs." A closely related FDR control methodology has long been employed in the analysis of mass spectrometry data, referr …
Recently, Barber and Candes laid the theoretical foundation for a general framework for false discovery rate (FDR) control based on t …
A statistical method for the conservative adjustment of false discovery rate (q-value).
Lai Y. Lai Y. BMC Bioinformatics. 2017 Mar 14;18(Suppl 3):69. doi: 10.1186/s12859-017-1474-6. BMC Bioinformatics. 2017. PMID: 28361675 Free PMC article.
BACKGROUND: q-value is a widely used statistical method for estimating false discovery rate (FDR), which is a conventional significance measure in the analysis of genome-wide expression data. q-value is a random variable and it may underestimate FDR in practi …
BACKGROUND: q-value is a widely used statistical method for estimating false discovery rate (FDR), which is a conventional sig …
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury.
Proctor WR, Foster AJ, Vogt J, Summers C, Middleton B, Pilling MA, Shienson D, Kijanska M, Ströbel S, Kelm JM, Morgan P, Messner S, Williams D. Proctor WR, et al. Arch Toxicol. 2017 Aug;91(8):2849-2863. doi: 10.1007/s00204-017-2002-1. Epub 2017 Jun 13. Arch Toxicol. 2017. PMID: 28612260 Free PMC article.
Compounds were treated long-term (14 days) in hLiMT and acutely (2 days) in PHH to assess drug-induced cytotoxicity over an 8-point concentration range to generate IC(50) values. Regardless of comparing IC(50) values or exposure-corrected margin of safety values …
Compounds were treated long-term (14 days) in hLiMT and acutely (2 days) in PHH to assess drug-induced cytotoxicity over an 8-point concentr …
32,290 results
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